Assessment of apoB dyslipoproteinemia in Korean population

Abstract

Objectives: There is sparse data on apoB dyslipoproteinemia in Asian population. The purpose of this study was to assess apoB dyslipoproteinemia and to compare the LDL-C, non-HDL and apoB for risk assessment with percentile equivalent cut off in Korean population.

Methods: With 1193 Korean adult subjects, the prevalence and characteristics of different types of dyslipoproteinemias were analyzed in each age and gender group. The percentile values of direct LDL-C, calculated LDL-C, non HDL-C, HDL-C, apoAI, apoB and apoB/apoAI ratio were estimated.

Results: The prevalences of normoapoB-hyperTG, hyperapoB-normoTG and hyperapoB-hyperTG dyslipoproteinemia were 6.9, 8.9 and 10.9% in men and 3.7, 6.4 and 2.8% in women. The 40th percentile of direct LDL-C, calculated LDL-C, non-HDL-C and apo B were 108, 104.2, 126 and 85 mg/dl, respectively. The individual above optimal cut off was significantly underestimated with LDL-C than with non-HDL and apoB, in groups with adverse risk factors.

Conclusions: This study firstly shows the prevalence of various types of dyslipoproteinemias in Asian population. The percentile values of Korean population were similar to those of NHANES. Integration of lipid markers is needed for making clinical decisions and further research involving various populations and methodologies should be performed.

Keywords: ACA; ADA; ATP; Adult Treatment Panel; American College of Cardiology; American Diabetes Association; Apolipoprotein B; BMI; Dyslipoproteinemia; HDL-C; IDF; IDL; International Diabetes Federation; Korean; LDL; LDL-C; MetS; NCEP; NHANES; National Cholesterol Education Program; National Health and Nutrition Examination Survey; Percentile; TC; VLDL; apoB; apolipoprotein B; body mass index; high-density lipoprotein, TG, triglyceride; intermediate-density lipoprotein; low-density lipoprotein cholesterol; metabolic syndrome; total cholesterol; very low-density lipoprotein.