Emergence of Klebsiella pneumoniae co-producing NDM-type and OXA-181 carbapenemases

Clin Microbiol Infect. 2013 Sep;19(9):E421-3. doi: 10.1111/1469-0691.12247. Epub 2013 May 13.

Abstract

The emergence of carbapenemase-producing Enterobacteriaceae is a rapidly evolving threat worldwide. Here, we report the molecular characterization of two Klebsiella pneumoniae isolates carrying both bla(OXA -181) and bla(NDM -1) or bla(NDM -5) isolated from epidemiologically unrelated patients in Singapore. The bla(OXA -181) genes were found existing in different genetic environments.

Keywords: Carbapenemases; Enterobacteriaceae; gram-negative resistance; metallo-β-lactamases; oxacillinases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism*
  • Bacterial Typing Techniques
  • Child, Preschool
  • Enterobacteriaceae / genetics
  • Female
  • Humans
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / genetics*
  • Klebsiella pneumoniae / isolation & purification
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • Prospective Studies
  • Singapore
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism*

Substances

  • Bacterial Proteins
  • beta-Lactamases
  • beta-lactamase NDM-1
  • carbapenemase