Abstract
This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response.In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.
MeSH terms
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Airway Remodeling / immunology*
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Humans
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Immunoglobulin E / immunology
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Matrix Metalloproteinase 7 / physiology
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Matrix Metalloproteinase 9 / physiology
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Nasal Polyps / immunology
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Nasal Polyps / microbiology
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Nasal Polyps / physiopathology*
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Rhinitis / immunology
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Rhinitis / microbiology
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Sinusitis / immunology
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Sinusitis / microbiology
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Staphylococcus aureus
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Superantigens / physiology
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Transforming Growth Factor beta1 / physiology
Substances
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Superantigens
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Transforming Growth Factor beta1
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Immunoglobulin E
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Matrix Metalloproteinase 7
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Matrix Metalloproteinase 9