RNA-DNA hybrid origami: folding of a long RNA single strand into complex nanostructures using short DNA helper strands

Pengfei Wang; Seung Hyeon Ko; Cheng Tian; Chenhui Hao; Chengde Mao

doi:10.1039/c3cc41707g

RNA-DNA hybrid origami: folding of a long RNA single strand into complex nanostructures using short DNA helper strands

Chem Commun (Camb). 2013 Jun 18;49(48):5462-4. doi: 10.1039/c3cc41707g. Epub 2013 May 10.

Authors

Pengfei Wang¹, Seung Hyeon Ko, Cheng Tian, Chenhui Hao, Chengde Mao

Affiliation

¹ Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.

PMID: 23660602
DOI: 10.1039/c3cc41707g

Abstract

Quick folding of a long RNA strand using short DNA staple strands (at a 1 : 1 ratio) into various pre-designed nanostructures in high yields has been demonstrated.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

DNA, Single-Stranded / metabolism*
Microscopy, Confocal
Nanostructures / chemistry*
Nucleic Acid Conformation
Nucleic Acid Hybridization
RNA / chemistry
RNA / metabolism*

Substances

DNA, Single-Stranded
RNA