Objective: To explore different risk factors between anterior and posterior circulation affecting onset and prognosis in the North Chinese young ischemic stroke patients.
Methods: This study included 446 cases of young ischemic stroke patients in northern China. All patients were recruited from our department from 2001 to 2010, Among them, the lesion sites were anterior circulation infarction (n = 353), posterior circulation infarction (n = 56) and both anterior and posterior circulation infarction (n = 37). Non-conditional Logistic regression analysis was used to determine the risk factors of predicting the onset of either anterior or posterior or mixed stroke and their short-term prognosis.
Results: Advanced age and a higher white blood cell count (WBC) increased the risk of non-anterior circulation lesions (OR 0.951, P = 0.030; OR 0.876, P = 0.014). Patients with a history of alcohol drinking had an increased risk for simple posterior circulation lesions (OR 1.856, P = 0.047); Both high National Institute of Health stroke scale (NIHSS score) and high total cholesterol (TC) predicted a poor short-term prognosis for simple anterior circulation lesions (OR 1.884, P = 0.000; OR 1.792, P = 0.008).
Conclusion: Age, WBC count, alcohol intake, NIHSS score and TC are closely correlated with different lesions of northern Chinese young patients with ischemic stroke and their poor short-term prognosis.