Abstract
Vitamin D deficiency is highly prevalent in patients with chronic kidney disease (CKD). The low vitamin D status is, to a large extent, caused by dysregulation of vitamin D metabolism as a result of renal insufficiency. Recent studies indicate that vitamin D-deficiency may promote or accelerate the progression of CKD, whereas treatment with low calcemic vitamin D analogs can reduce proteinuria and ameliorate renal damage in animal models of kidney disease and in patients with CKD. The renoprotective activity of vitamin D regulates multiple signaling pathways known to play important roles in renal injury. These findings underscore the importance of correcting vitamin D deficiency with vitamin D supplementation or with activated vitamin D analogs in the management of CKD.
Copyright © 2013 S. Karger AG, Basel.
MeSH terms
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Animals
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Chronic Kidney Disease-Mineral and Bone Disorder / metabolism
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Disease Progression
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Gene Expression Regulation
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Humans
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Hyperparathyroidism, Secondary / drug therapy
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Hyperparathyroidism, Secondary / etiology
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Hyperparathyroidism, Secondary / prevention & control
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Inflammation / metabolism
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Kidney / physiopathology
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Kidney Glomerulus / metabolism
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Models, Biological
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NF-kappa B / metabolism
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Podocytes / metabolism
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Prevalence
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Proteinuria / etiology
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Proteinuria / prevention & control
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Rats
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Renal Dialysis / adverse effects
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Renal Insufficiency, Chronic / complications
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Renal Insufficiency, Chronic / metabolism*
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Renal Insufficiency, Chronic / mortality
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Renal Insufficiency, Chronic / prevention & control
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Renal Insufficiency, Chronic / therapy
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Renin-Angiotensin System / physiology
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Steroid Hydroxylases / physiology
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Vitamin D / agonists
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Vitamin D / physiology*
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Vitamin D / therapeutic use
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Vitamin D Deficiency / drug therapy
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Vitamin D Deficiency / epidemiology
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Vitamin D Deficiency / etiology
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Vitamin D Deficiency / metabolism*
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Vitamin D3 24-Hydroxylase
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Wnt Signaling Pathway
Substances
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NF-kappa B
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Vitamin D
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Steroid Hydroxylases
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Vitamin D3 24-Hydroxylase