Emerging roles of Cdk8 in cell cycle control

Zsolt Szilagyi; Claes M Gustafsson

doi:10.1016/j.bbagrm.2013.04.010

Emerging roles of Cdk8 in cell cycle control

Biochim Biophys Acta. 2013 Sep;1829(9):916-20. doi: 10.1016/j.bbagrm.2013.04.010. Epub 2013 May 1.

Authors

Zsolt Szilagyi¹, Claes M Gustafsson

Affiliation

¹ Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Sweden. zsolt.szilagyi@medkem.gu.se

PMID: 23643644
DOI: 10.1016/j.bbagrm.2013.04.010

Abstract

Cyclin dependent kinase 8 (Cdk8) is a component of Mediator, an evolutionary conserved multiprotein complex that regulates RNA polymerase II-dependent transcription. Cdk8 has been implicated as a regulator of multiple steps in cell cycle progression. We here discuss recent advances in our understanding of Cdk8 function and a possible role for Mediator as a hub for integrating transcription regulation with cell cycle progression.

Keywords: Differentiation; Mediator; Mitosis; Protein stability; Stem cells; Wnt/β-catenin signaling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Cycle / physiology*
Cyclin-Dependent Kinase 8 / physiology*
RNA Polymerase II / metabolism
Saccharomyces cerevisiae / cytology*
Saccharomyces cerevisiae Proteins / physiology*

Substances

Saccharomyces cerevisiae Proteins
Cyclin-Dependent Kinase 8
SSN3 protein, S cerevisiae
RNA Polymerase II