Organobase-catalyzed amidation of esters with amino alcohols

Nicola Caldwell; Craig Jamieson; Iain Simpson; Tell Tuttle

doi:10.1021/ol400987p

Organobase-catalyzed amidation of esters with amino alcohols

Org Lett. 2013 May 17;15(10):2506-9. doi: 10.1021/ol400987p. Epub 2013 May 2.

Authors

Nicola Caldwell¹, Craig Jamieson, Iain Simpson, Tell Tuttle

Affiliation

¹ Department of Pure and Applied Chemistry, University of Strathclyde , 295 Cathedral Street, Glasgow, G1 1XL, U.K., and AstraZeneca , Oncology Innovative Medicines Unit, Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K.

PMID: 23639049
DOI: 10.1021/ol400987p

Abstract

A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemistry*
Amino Alcohols / chemistry*
Catalysis
Esters
Molecular Structure
Stereoisomerism

Substances

Amides
Amino Alcohols
Esters