Presence of human papilloma virus in a series of breast carcinoma from Argentina

Ana Laura Pereira Suarez; Mario Alejandro Lorenzetti; Rene Gonzalez Lucano; Melina Cohen; Hugo Gass; Paula Martinez Vazquez; Pedro Gonzalez; Maria V Preciado; Paola Chabay

doi:10.1371/journal.pone.0061613

Presence of human papilloma virus in a series of breast carcinoma from Argentina

PLoS One. 2013 Apr 25;8(4):e61613. doi: 10.1371/journal.pone.0061613. Print 2013.

Authors

Ana Laura Pereira Suarez¹, Mario Alejandro Lorenzetti, Rene Gonzalez Lucano, Melina Cohen, Hugo Gass, Paula Martinez Vazquez, Pedro Gonzalez, Maria V Preciado, Paola Chabay

Affiliation

¹ Department of Physiology, University Center for Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico.

Abstract

Background: The etiology and the molecular mechanisms related to breast carcinogenesis remain poorly understood. Some recent reports have examined the role of Human Papillomavirus (HPV) in this disease. The purpose of this study was to determine the prevalence of HPV in breast cancer.

Methods: Sixty one fresh frozen breast cancers samples were analyzed. Samples were tested for HPV by PCR, and products were automatically sequenced. Findings were correlated with clinical and pathological characteristics.

Results: The HPV DNA prevalence in the breast cancer samples was 26% (16/61). Clinical parameters were not statistically associated with HPV presence (p>0.05 χ(2) test). Sequence analysis in a subgroup of cases indicates the prevalence of low risk HPV11, followed by high risk HPV16. We found no HPV transcriptional activity.

Conclusion: The present study demonstrated for the first time in Argentina the presence of HPV in a proportion of the malignant breast tissues. This finding suggests that HPV may have a biological significance in breast carcinogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Argentina
Breast Neoplasms / pathology
Breast Neoplasms / virology*
Female
Human papillomavirus 11 / genetics
Human papillomavirus 11 / isolation & purification*
Human papillomavirus 11 / physiology*
Human papillomavirus 16 / genetics
Human papillomavirus 16 / isolation & purification*
Human papillomavirus 16 / physiology*
Humans
Middle Aged
Risk

Grants and funding

This study was supported in part by a grant from National Agency for Science and Technology Promotion (PICT 2007 n°1071), and a grant from National Ministry of Science – Conacty (Mex 0717). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.