Synthesis of (E)-nitroolefins via decarboxylative nitration using t-butylnitrite (t-BuONO) and TEMPO

Chem Commun (Camb). 2013 Jun 11;49(46):5286-8. doi: 10.1039/c3cc41576g.

Abstract

Nitroolefins are usually synthesized using the Henry reaction. Here we report an alternative metal-free decarboxylative nitration protocol for the preparation of the nitroolefins from α,β-unsaturated carboxylic acids using t-butylnitrite (t-BuONO) and TEMPO. α,β-Unsaturated carboxylic acids bearing β-aromatic and β-heteroaromatic substituents gave (E)-nitroolefins exclusively under mild conditions. A radical based pathway has been proposed for this decarboxylative nitration reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis*
  • Alkenes / chemistry
  • Carboxylic Acids / chemistry
  • Cyclic N-Oxides / chemistry*
  • Decarboxylation
  • Nitrites / chemistry*
  • Nitro Compounds / chemical synthesis*
  • Nitro Compounds / chemistry

Substances

  • Alkenes
  • Carboxylic Acids
  • Cyclic N-Oxides
  • Nitrites
  • Nitro Compounds
  • n-butyl nitrite
  • TEMPO