Breakthrough disseminated cryptococcosis during micafungin therapy

Wen-Sen Lee; Tai-Chin Hsieh; Tsong-Yih Ou; Sing-On Teng; Fu-Lun Chen; Fu-Der Wang

doi:10.1016/j.jmii.2013.03.002

Breakthrough disseminated cryptococcosis during micafungin therapy

J Microbiol Immunol Infect. 2015 Aug;48(4):456-8. doi: 10.1016/j.jmii.2013.03.002. Epub 2013 Apr 28.

Authors

Wen-Sen Lee¹, Tai-Chin Hsieh¹, Tsong-Yih Ou¹, Sing-On Teng¹, Fu-Lun Chen¹, Fu-Der Wang²

Affiliations

¹ Division of Infectious Disease, Department of Internal Medicine, Wan Fang Medical Center, Taipei Medical University, Taipei, Taiwan.
² Division of Infectious Disease, Department of Internal Medicine, Taipei Veterans General Hospital, National Yang-Ming University of Medicine, Taipei, Taiwan. Electronic address: 89425@wanfang.gov.tw.

PMID: 23632603
DOI: 10.1016/j.jmii.2013.03.002

Abstract

Echinocandins are not active against basidiomycetous yeasts, such as Cryptococcus neoformans, Trichosporon, and Rhodotorula species, and zygomycosis. We present a patient with renal failure and candidemia, who developed a breakthrough fungal infection with cryptococcemia and cryptococcuria while receiving micafungin therapy.

Keywords: Breakthrough fungal infection; Cryptococcosis; Micafungin.

Publication types

Case Reports

MeSH terms

Aged
Antifungal Agents / therapeutic use*
Candidiasis / complications
Cryptococcosis / complications*
Cryptococcosis / drug therapy*
Cryptococcus neoformans / isolation & purification*
Echinocandins / therapeutic use*
Fungemia / diagnosis*
Fungemia / pathology*
Humans
Lipopeptides / therapeutic use*
Male
Micafungin
Renal Insufficiency / complications

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Micafungin