Wavelength-multiplexing phase-sensitive surface plasmon imaging sensor

Opt Lett. 2013 May 1;38(9):1370-2. doi: 10.1364/OL.38.001370.

Abstract

A wavelength-multiplexing phase-sensitive surface plasmon resonance (SPR) imaging sensor offering wide dynamic detection range and microarray capability is reported. Phase detection is accomplished by performing self-interference between the s- and p- polarizations within the signal beam. A liquid crystal tunable filter is used to sequentially select the SPR excitation wavelength from a white light source. This wavelength-multiplexing approach enables fast detection of the sensor's SPR phase response over a wide range of wavelengths, thereby covering literally any regions of interest within the SPR dip and thus maintaining the highest sensitivity point at all times. The phase-sensitive approach is particularly important for imaging SPR sensing applications because of its less stringent requirements for intensity signal-to-noise ratio, which also means the possibility of using uncooled modest resolution analog-to-digital conversion imaging devices. Experimental results demonstrate a resolution of 2.7×10(-7) RIU with a dynamic range of 0.0138 RIU.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Glycerol / chemistry
  • Humans
  • Immunoglobulin G / immunology
  • Optical Imaging / methods*
  • Surface Plasmon Resonance / methods*
  • Water / chemistry

Substances

  • Immunoglobulin G
  • Water
  • Glycerol