In vitro electrochemical corrosion and cell viability studies on nickel-free stainless steel orthopedic implants

Erfan Salahinejad; Mohammad Jafar Hadianfard; Digby Donald Macdonald; Samin Sharifi-Asl; Masoud Mozafari; Kenneth J Walker; Armin Tahmasbi Rad; Sundararajan V Madihally; Lobat Tayebi

doi:10.1371/journal.pone.0061633

In vitro electrochemical corrosion and cell viability studies on nickel-free stainless steel orthopedic implants

PLoS One. 2013 Apr 22;8(4):e61633. doi: 10.1371/journal.pone.0061633. Print 2013.

Authors

Erfan Salahinejad¹, Mohammad Jafar Hadianfard, Digby Donald Macdonald, Samin Sharifi-Asl, Masoud Mozafari, Kenneth J Walker, Armin Tahmasbi Rad, Sundararajan V Madihally, Lobat Tayebi

Affiliation

¹ Department of Materials Science and Engineering, School of Engineering, Shiraz University, Shiraz, Iran.

Abstract

The corrosion and cell viability behaviors of nanostructured, nickel-free stainless steel implants were studied and compared with AISI 316L. The electrochemical studies were conducted by potentiodynamic polarization and electrochemical impedance spectroscopic measurements in a simulated body fluid. Cytocompatibility was also evaluated by the adhesion behavior of adult human stem cells on the surface of the samples. According to the results, the electrochemical behavior is affected by a compromise among the specimen's structural characteristics, comprising composition, density, and grain size. The cell viability is interpreted by considering the results of the electrochemical impedance spectroscopic experiments.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemistry*
Biocompatible Materials / toxicity
Cell Adhesion
Cell Survival
Cells, Cultured
Corrosion
Electric Impedance
Electrochemistry
Humans
Materials Testing
Mesenchymal Stem Cells / physiology*
Mesenchymal Stem Cells / ultrastructure
Nickel / chemistry
Orthopedics
Powders / chemistry
Prostheses and Implants*
Stainless Steel / chemistry*
Stainless Steel / toxicity
X-Ray Diffraction

Substances

Biocompatible Materials
Powders
Stainless Steel
Nickel

Grants and funding

This work was supported by the Oklahoma Center for Advancement of Science and Technology under Grant no. HR12-023. No additional external funding was received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.