Dual-purpose PEG scaffolds for the preparation of soft and biofunctional hydrogels: the convergence between CuAAC and thiol-ene reactions

Chem Commun (Camb). 2013 Aug 11;49(62):6938-40. doi: 10.1039/c3cc42084a.

Abstract

Orthogonally functionalized PEGs displaying alkenes and azides have been prepared and their dual-purpose scaffolding potential was exploited via click chemistry for controlled insertion of biorelevant moieties as well as facile fabrication of soft, non-toxic and degradable hydrogels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Azides / chemistry*
  • Catalysis
  • Cell Survival
  • Copper / chemistry*
  • Cyclization
  • Fibroblasts / cytology
  • Humans
  • Hydrogels / chemical synthesis*
  • Hydrogels / chemistry
  • Molecular Structure
  • Polyethylene Glycols / chemistry*
  • Sulfhydryl Compounds / chemistry*

Substances

  • Alkynes
  • Azides
  • Hydrogels
  • Sulfhydryl Compounds
  • Polyethylene Glycols
  • Copper