Gene of the month: KRAS

J Clin Pathol. 2013 Jul;66(7):548-50. doi: 10.1136/jclinpath-2013-201663. Epub 2013 Apr 27.

Authors

Runjan Chetty¹, Dhirendra Govender

Affiliation

¹ Department of Cellular Pathology and Nuffield Department of Clinical Laboratory Sciences, Oxford Biomedical Research Centre, Oxford University Hospitals Trust and University of Oxford University, Oxford, UK. runjan.chetty@gmail.com

PMID: 23626007
DOI: 10.1136/jclinpath-2013-201663

Abstract

This is a general overview of KRAS, its structure and role in pertinent cancers. Also its role in determining adjuvant therapy is discussed.

Keywords: Cancer; Genetics; Molecular pathology.

Publication types

Review

MeSH terms

Chemotherapy, Adjuvant
Female
Gene Expression Regulation, Neoplastic*
Humans
Male
Mutation*
Neoplasms / drug therapy
Neoplasms / genetics*
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins p21(ras)
ras Proteins / genetics*

Substances

KRAS protein, human
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
ras Proteins