Liberation of drugs from multi-wall carbon nanotube carriers

Sławomir Boncel; Piotr Zając; Krzysztof K K Koziol

doi:10.1016/j.jconrel.2013.04.009

Liberation of drugs from multi-wall carbon nanotube carriers

J Control Release. 2013 Jul 10;169(1-2):126-40. doi: 10.1016/j.jconrel.2013.04.009. Epub 2013 Apr 24.

Authors

Sławomir Boncel¹, Piotr Zając, Krzysztof K K Koziol

Affiliation

¹ Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, Krzywoustego 4, Gliwice 44-100, Poland. slawomir.boncel@polsl.pl

PMID: 23624360
DOI: 10.1016/j.jconrel.2013.04.009

Abstract

MWCNTs in the 'nanotube-drug' hybrids can play a role of carriers or additives (enhancers) in the more complex formulations. This work reviews qualitative and quantitative analyses of Drug Delivery Systems (DDSs) based on multi-wall carbon nanotubes (MWCNTs) and their chemically modified analogues (mainly oxidised MWCNTs). A special emphasis was placed on the chemical interactions between drug molecules and the nanotube carrier critical both in the stage of preparation/synthesis of the hybrids and liberation of the drug.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Drug Carriers / chemistry*
Drug Delivery Systems / methods*
Humans
Nanotubes, Carbon / chemistry*
Nanotubes, Carbon / ultrastructure
Oxidation-Reduction
Pharmaceutical Preparations / administration & dosage*
Pharmaceutical Preparations / chemistry

Substances

Drug Carriers
Nanotubes, Carbon
Pharmaceutical Preparations