Non-destructive multibiomarker approach in European quail (Coturnix coturnix coturnix) exposed to the herbicide atrazine

Arch Environ Contam Toxicol. 2013 Oct;65(3):567-74. doi: 10.1007/s00244-013-9907-3. Epub 2013 Apr 26.

Abstract

The effect of orally administered atrazine (25 or 100 mg/kg on days 0, 5, and 10 of the experiment) was studied in European quail (Coturnix coturnix coturnix) on four non-destructive biomarkers: fecal porphyrins, blood glutathione-S-transferase, glutathione reductase, reduced glutathione, and malondialdehyde (MDA). Uroporphyrin I (UPI) and coproporphyrins I and III (CPIII) were the main porphyrins detected in feces. The lowest dose of ATZ caused a significant (P < 0.05) increase in UPI and CPIII at day 5, and the highest dose of ATZ caused an induction of CPI and a significant (P < 0.05) decrease in MDA levels at day 30.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atrazine / toxicity*
  • Biomarkers / metabolism
  • Chromatography, High Pressure Liquid
  • Coturnix / metabolism*
  • Environmental Exposure*
  • Feces / chemistry
  • Female
  • Fluorometry
  • Glutathione / blood
  • Glutathione Reductase / blood
  • Glutathione Transferase / blood
  • Herbicides / toxicity*
  • Lipid Peroxidation / drug effects*
  • Malondialdehyde / blood
  • Oxidative Stress / drug effects*
  • Porphyrins / metabolism
  • Spectrophotometry

Substances

  • Biomarkers
  • Herbicides
  • Porphyrins
  • Malondialdehyde
  • Glutathione Reductase
  • Glutathione Transferase
  • Glutathione
  • Atrazine