Set them free: F-box protein exchange by Cand1

Karin Flick; Peter Kaiser

doi:10.1038/cr.2013.55

Set them free: F-box protein exchange by Cand1

Cell Res. 2013 Jul;23(7):870-1. doi: 10.1038/cr.2013.55. Epub 2013 Apr 23.

Authors

Karin Flick¹, Peter Kaiser

Affiliation

¹ Department of Biological Chemistry, School of Medicine, University of California Irvine, 240D Med Sci I, Irvine, CA 92697-1700, USA.

Abstract

Cand1 (Cullin-associated and neddylation-dissociated protein 1) has long been known as a regulator of SCF ubiquitin ligases, but details remained puzzling due to conflicting results from in vitro and in vivo experiments. Three recent reports, one in Cell and two in Nature Communications, propose Cand1 as a protein exchange factor with interesting mechanism that reconciles Cand1 genetics and biochemistry.

Publication types

Comment

MeSH terms

Animals
Humans
SKP Cullin F-Box Protein Ligases / metabolism*
Saccharomyces cerevisiae / physiology*
Saccharomyces cerevisiae Proteins / physiology*
Schizosaccharomyces / metabolism*
Schizosaccharomyces pombe Proteins / metabolism*
Transcription Factors / metabolism*

Substances

Saccharomyces cerevisiae Proteins
Schizosaccharomyces pombe Proteins
Transcription Factors
SKP Cullin F-Box Protein Ligases