Standing out from the crowd: cancer stem cells in hepatocellular carcinoma

Bruno Sainz Jr; Christopher Heeschen

doi:10.1016/j.ccr.2013.03.023

Standing out from the crowd: cancer stem cells in hepatocellular carcinoma

Cancer Cell. 2013 Apr 15;23(4):431-3. doi: 10.1016/j.ccr.2013.03.023.

Authors

Bruno Sainz Jr¹, Christopher Heeschen

Affiliation

¹ Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.

PMID: 23597561
DOI: 10.1016/j.ccr.2013.03.023

Abstract

Cancer stem cells (CSCs) drive solid tumor formation. In this issue of Cancer Cell, Zhao and colleagues indentify the calcium channel α2δ1 subunit as a new functional hepatocellular carcinoma (HCC) CSC biomarker, which is vital for CSC biology as blocking α2δ1 in combination with doxorubicin treatment hinders HCC tumor formation.

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