The study aimed to analyze the nurses' perception about the use of the Information System of Primary Care (ISPC) in the Family Health Strategy (FHS) in five cities in the South. Five nurses were interviewed and data were analyzed following the steps of thematic analysis, two categories emerge: possibilities of using the ISPC and challenges faced in everyday nurse using the ISPC. Stresses the importance of the Regional Health Coordination in organizing training and discussions on the ISPC, and assist municipalities in the effective implementation of this system in primary care, involving managers, employees and community. Greater involvement of these actors in the consolidation of ISPC facilitate and qualify the actions of the population health planning.