Abstract
To evaluate the impact of influenza C (ICV) infection in children with community-acquired pneumonia (CAP), all of the children consecutively seen during 4 influenza seasons with respiratory symptoms and radiographically confirmed CAP were prospectively evaluated. ICV was identified in the respiratory secretions of five of 391 patients (1·3%). In children with ICV-associated CAP, clinical data were similar to those observed in children with IAV-associated CAP and worse than those observed in children with IBV-associated. The phylogenetic tree showed that the sequenced strains clustered in two of the six ICV lineages. These findings highlight that ICV can be a cause of CAP of children and that this can be severe enough to require hospitalization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Child
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Child, Preschool
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Cluster Analysis
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Community-Acquired Infections / epidemiology*
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Community-Acquired Infections / pathology
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Community-Acquired Infections / virology*
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Female
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Gammainfluenzavirus / classification
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Gammainfluenzavirus / genetics
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Gammainfluenzavirus / isolation & purification*
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Humans
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Infant
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Influenza, Human / epidemiology*
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Influenza, Human / pathology
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Influenza, Human / virology*
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Male
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Molecular Sequence Data
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Phylogeny
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Pneumonia, Viral / epidemiology*
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Pneumonia, Viral / pathology
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Pneumonia, Viral / virology*
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RNA, Viral / genetics
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Radiography, Thoracic
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Sequence Analysis, DNA
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Sequence Homology
Associated data
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GENBANK/JX129180
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GENBANK/JX129181
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GENBANK/JX129182
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GENBANK/JX129183
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GENBANK/JX129184