Abstract
In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC₅₀ values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Annona / chemistry*
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Anti-Inflammatory Agents / analysis
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Inhibitory Concentration 50
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Lipopolysaccharides / adverse effects
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Macrophages / drug effects
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Magnetic Resonance Spectroscopy
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Mice
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide / biosynthesis
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Leaves / chemistry*
Substances
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Anti-Inflammatory Agents
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Lipopolysaccharides
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Plant Extracts
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Nitric Oxide