Subungual acrolentiginous amelanotic melanoma treated with amputation of the distal and middle phalanges

Wien Med Wochenschr. 2013 Aug;163(15-16):368-71. doi: 10.1007/s10354-013-0194-4. Epub 2013 Apr 17.

Abstract

Acral lentiginous melanoma (ALM) is an uncommon melanoma type among Caucasions. ALM bears an unfavorable prognosis because of late presentation or common misdiagnosis. Amelanotic variants, albeit rare, may pose an additional clinical challenge and may further delay the diagnosis and treatment. Thus, the threshold for biopsying even marginally suspicious lesions should be low. We present two cases of Caucasian patients with amelanotic subungual ALM, stage 2a and 2c respectively, successfully treated with a functional amputation.

MeSH terms

  • Amputation, Surgical*
  • Antineoplastic Agents / therapeutic use*
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Dose-Response Relationship, Drug
  • Fingers / pathology
  • Fingers / surgery*
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / therapeutic use*
  • Melanoma, Amelanotic / drug therapy*
  • Melanoma, Amelanotic / pathology
  • Melanoma, Amelanotic / surgery*
  • Nail Diseases / drug therapy*
  • Nail Diseases / pathology
  • Nail Diseases / surgery*
  • Neoplasm Staging
  • Prognosis
  • Recombinant Proteins / therapeutic use
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / mortality
  • Skin Neoplasms / pathology
  • Skin Neoplasms / surgery*

Substances

  • Antineoplastic Agents
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins