Synthesis of various secosteroidal macrocycles by ring-closing metathesis

Abstract

We set out to describe an efficient and versatile method for preparing secosteroidal macrocycles from cholic acid, via an oxidative ring-expansion/ring-opening sequence and a ring-closing metathesis reaction as the key steps. The characteristic ¹H and ¹³C NMR spectroscopic features of the synthesized compounds are reported.