Multivalent presentation of a hydrolytically stable GM(3) lactone mimetic as modulator of melanoma cells motility and adhesion

Barbara Richichi; Giuseppina Comito; Linda Cerofolini; Gabriele Gabrielli; Alberto Marra; Lisa Moni; Alice Pace; Lucia Pasquato; Paola Chiarugi; Alessandro Dondoni; Lucio Toma; Cristina Nativi

doi:10.1016/j.bmc.2013.03.021

Multivalent presentation of a hydrolytically stable GM(3) lactone mimetic as modulator of melanoma cells motility and adhesion

Bioorg Med Chem. 2013 May 15;21(10):2756-63. doi: 10.1016/j.bmc.2013.03.021. Epub 2013 Mar 24.

Authors

Barbara Richichi¹, Giuseppina Comito, Linda Cerofolini, Gabriele Gabrielli, Alberto Marra, Lisa Moni, Alice Pace, Lucia Pasquato, Paola Chiarugi, Alessandro Dondoni, Lucio Toma, Cristina Nativi

Affiliation

¹ Department of Chemistry, University of Florence, via della Lastruccia 3, 13 50019 Sesto F. no, FI, Italy.

PMID: 23583030
DOI: 10.1016/j.bmc.2013.03.021

Abstract

A hydrolytically stable mimetic of the tumour antigen GM(3) lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion, migration and resistance to apoptosis (anoikis). Notably, their ability to hamper melanoma-cells adhesion and reduce the metastatic potential is enhanced when the two scaffolds, presenting a different shape, are used in combination.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects
Biomimetic Materials / chemistry
Biomimetic Materials / pharmacology*
Cell Adhesion / drug effects
Cell Movement / drug effects*
G(M3) Ganglioside / analogs & derivatives*
G(M3) Ganglioside / chemistry
Humans
Melanoma / metabolism
Melanoma / pathology*

Substances

G(M3) Ganglioside
ganglioside GM3 lactone