Health care settings offer an important opportunity to reduce the burden of harm associated with SUD. This paper provides health care professionals with a range of clinical protocols and implementation methods that can improve the care of patients and their families who are affected by these disorders. It is time for health care professionals to change the system. It is time for university presidents, chancellors, and deans to take responsibility for a problem too long neglected. Through education and united efforts, we can effect changes that will improve the health of our patients and communities.