Effects of antimicrobial peptide revealed by simulations: translocation, pore formation, membrane corrugation and euler buckling

Int J Mol Sci. 2013 Apr 11;14(4):7932-58. doi: 10.3390/ijms14047932.

Abstract

We explore the effects of the peripheral and transmembrane antimicrobial peptides on the lipid bilayer membrane by using the coarse grained Dissipative Particle Dynamics simulations. We study peptide/lipid membrane complexes by considering peptides with various structure, hydrophobicity and peptide/lipid interaction strength. The role of lipid/water interaction is also discussed. We discuss a rich variety of membrane morphological changes induced by peptides, such as pore formation, membrane corrugation and Euler buckling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimicrobial Cationic Peptides / chemistry*
  • Lipid Bilayers / chemistry*
  • Models, Chemical*

Substances

  • Antimicrobial Cationic Peptides
  • Lipid Bilayers