Lobectomy requiring chest wall resection is usually performed by thoracotomy, but thanks to the advances in the field of thoracoscopic surgery, this procedure can be performed by video-assisted thoracoscopic surgery (VATS). Recent improvements in surgical devices and previous VATS experience have allowed this complex surgery for advanced stages to be undertaken safely. Most of the thoracoscopic lobectomies with rib resection are performed using three to four incisions. We report a different minimally invasive technique for chest wall resection (minimally invasive posterior approach) and VATS right upper lobectomy (single-incision anterior approach).