A turn-on fluorescent probe for detection of tyrosinase activity

Analyst. 2013 May 21;138(10):2825-8. doi: 10.1039/c3an00272a.

Abstract

We have presented a fluorescent probe that exhibits a fluorescence turn-on signal upon reaction with tyrosinase, and we show that it can be readily employed for the assessment of tyrosinase activity and tyrosinase inhibitor activities in buffered aqueous solution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzaldehydes / chemistry
  • Benzaldehydes / pharmacology
  • Benzoic Acid / chemistry
  • Benzoic Acid / pharmacology
  • Enzyme Activation / drug effects
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Fluorescence
  • Fluorescent Dyes / chemistry*
  • Monophenol Monooxygenase / analysis*
  • Monophenol Monooxygenase / antagonists & inhibitors
  • Monophenol Monooxygenase / metabolism
  • Oxadiazoles / chemistry*
  • Structure-Activity Relationship

Substances

  • Benzaldehydes
  • Enzyme Inhibitors
  • Fluorescent Dyes
  • Oxadiazoles
  • Benzoic Acid
  • Monophenol Monooxygenase
  • benzaldehyde