The nexus of Tet1 and the pluripotency network

Steven A Jackson; Rupa Sridharan

doi:10.1016/j.stem.2013.03.007

The nexus of Tet1 and the pluripotency network

Cell Stem Cell. 2013 Apr 4;12(4):387-8. doi: 10.1016/j.stem.2013.03.007.

Authors

Steven A Jackson¹, Rupa Sridharan

Affiliation

¹ Department of Cell and Regenerative Biology, Wisconsin Institute for Discovery, Epigenetics Theme, University of Wisconsin-Madison, Madison, WI 53706, USA.

PMID: 23561438
DOI: 10.1016/j.stem.2013.03.007

Abstract

Resetting DNA methylation and reactivation of pluripotency genes are late events in the formation of iPSCs. Recent work by Costa et al. (2013) and Gao et al. (2013) has examined the role of Tet proteins in the hydroxymethylation of pluripotency genes, with the latter replacing Oct4 with Tet1 for reprogramming.

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