A 70-year-old woman, resident of a nursing home presented with complaints of fever for 1 day. Initial history, physical examination and laboratory tests were consistent with the diagnosis of systemic inflammatory response syndrome; blood culture from peripheral and central perm catheter were sent. Patient was started on empiric antibiotics and aggressive hydration. Blood cultures from peripheral access and central perm catheter grew Elisabethkingia meningoseptica on the second day. Patient was transferred to the intensive care unit for septic shock where patient needed vasopressors. Antibiotics were switched to intravenous trimethoprim-sulfamethoxazole, perm catheter was removed and catheter tip culture was sent. Catheter tip grew E meningoseptica (45 colony forming units). Patient showed excellent treatment response to intravenous trimethoprim-sulfamethoxazole and was weaned off pressors on day 4 with uneventful stay afterwards.