Protein-coated nanofibers for promotion of T cell activity

Chem Commun (Camb). 2013 May 11;49(38):3949-51. doi: 10.1039/c3cc41215f. Epub 2013 Apr 4.

Abstract

We have demonstrated that stable Concanavalin A (Con A)-coated supramolecular nanofibers can be constructed by complexation of self-assembled mannose nanofibers with Con A. The extended multivalent Con A nanofibers bind strongly to T cell surfaces and promote T cell activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Concanavalin A / chemistry
  • Concanavalin A / immunology*
  • Humans
  • Immobilized Proteins / chemistry
  • Immobilized Proteins / immunology*
  • Jurkat Cells
  • Lymphocyte Activation
  • Models, Molecular
  • Nanofibers / chemistry*
  • Nanofibers / ultrastructure
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*

Substances

  • Immobilized Proteins
  • Concanavalin A