Abstract
We have demonstrated that stable Concanavalin A (Con A)-coated supramolecular nanofibers can be constructed by complexation of self-assembled mannose nanofibers with Con A. The extended multivalent Con A nanofibers bind strongly to T cell surfaces and promote T cell activation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Concanavalin A / chemistry
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Concanavalin A / immunology*
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Humans
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Immobilized Proteins / chemistry
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Immobilized Proteins / immunology*
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Jurkat Cells
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Lymphocyte Activation
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Models, Molecular
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Nanofibers / chemistry*
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Nanofibers / ultrastructure
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
Substances
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Immobilized Proteins
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Concanavalin A