Amplitude-based data selection for optimal retrospective reconstruction in micro-SPECT

Phys Med Biol. 2013 Apr 21;58(8):2657-74. doi: 10.1088/0031-9155/58/8/2657. Epub 2013 Apr 3.

Abstract

Respiratory motion can blur the tomographic reconstruction of positron emission tomography or single-photon emission computed tomography (SPECT) images, which subsequently impair quantitative measurements, e.g. in the upper abdomen area. Respiratory signal phase-based gated reconstruction addresses this problem, but deteriorates the signal-to-noise ratio (SNR) and other intensity-based quality measures. This paper proposes a 3D reconstruction method dedicated to micro-SPECT imaging of mice. From a 4D acquisition, the phase images exhibiting motion are identified and the associated list-mode data are discarded, which enables the reconstruction of a 3D image without respiratory artefacts. The proposed method allows a motion-free reconstruction exhibiting both satisfactory count statistics and accuracy of measures. With respect to standard 3D reconstruction (non-gated 3D reconstruction) without breathing motion correction, an increase of 14.6% of the mean standardized uptake value has been observed, while, with respect to a gated 4D reconstruction, up to 60% less noise and an increase of up to 124% of the SNR have been demonstrated.

MeSH terms

  • Animals
  • Female
  • Imaging, Three-Dimensional / methods*
  • Mice
  • Peritoneal Neoplasms / diagnostic imaging
  • Peritoneal Neoplasms / physiopathology
  • Rats
  • Respiration
  • Retrospective Studies
  • Tomography, Emission-Computed, Single-Photon / methods*