Abstract
Inositol polyphosphate 4-phosphatase type II (Inpp4b) is a novel negative modulator of osteoclast differentiation and a prognostic locus for human osteoporosis. This short overview summarizes some of the cellular, molecular, and crosstalk signaling mechanisms that control osteoclast and osteoblast differentiation and activation.
© 2013 New York Academy of Sciences.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cell Differentiation*
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Humans
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Osteoblasts / cytology
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Osteoblasts / enzymology
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Osteoclasts / cytology*
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Osteoclasts / enzymology
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Osteoporosis / enzymology*
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Osteoporosis / pathology
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Phosphoric Monoester Hydrolases / metabolism*
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Signal Transduction
Substances
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Phosphoric Monoester Hydrolases
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phosphatidylinositol-3,4-bisphosphate 4-phosphatase