Inpp4b is a novel negative modulator of osteoclast differentiation and a prognostic locus for human osteoporosis

Ann N Y Acad Sci. 2013 Mar:1280:52-4. doi: 10.1111/nyas.12014.

Abstract

Inositol polyphosphate 4-phosphatase type II (Inpp4b) is a novel negative modulator of osteoclast differentiation and a prognostic locus for human osteoporosis. This short overview summarizes some of the cellular, molecular, and crosstalk signaling mechanisms that control osteoclast and osteoblast differentiation and activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation*
  • Humans
  • Osteoblasts / cytology
  • Osteoblasts / enzymology
  • Osteoclasts / cytology*
  • Osteoclasts / enzymology
  • Osteoporosis / enzymology*
  • Osteoporosis / pathology
  • Phosphoric Monoester Hydrolases / metabolism*
  • Signal Transduction

Substances

  • Phosphoric Monoester Hydrolases
  • phosphatidylinositol-3,4-bisphosphate 4-phosphatase