Abstract
Three new angucyclinones, saccharosporones A, B and C, together with (+)-ochromycinone, (+)-rubiginone B2, tetrangulol methyl ether and fujianmycin A, were obtained from fermentation of the terrestrial actinomycete of the genus Saccharopolyspora BCC 21906 isolated from a soil collected in Chanthaburi Province, Thailand. Structures of the new compounds and their relative configurations were assigned by NMR spectral data interpretation. Saccharosporones A and B exhibited antimalarial activity against Plasmodium falciparum K1 with IC50 values of 4.1 and 3.9 μM. Both metabolites also possessed cytotoxic activities against cancer cell lines (KB, MCF-7 and NCI-H187) and nonmalignant Vero cell, while saccharosporone C only showed cytotoxic activity against NCI-H187.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification*
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Anthraquinones / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Bacillus cereus / drug effects
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Benz(a)Anthracenes / isolation & purification
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Benz(a)Anthracenes / pharmacology
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Candida albicans / drug effects
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Chlorocebus aethiops
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Fermentation
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Humans
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Inhibitory Concentration 50
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KB Cells
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MCF-7 Cells
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Conformation
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Mycobacterium tuberculosis / drug effects
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Plasmodium falciparum / drug effects
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Saccharopolyspora / chemistry*
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Soil Microbiology*
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Thailand
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Vero Cells
Substances
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Anthraquinones
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Antifungal Agents
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Antimalarials
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Benz(a)Anthracenes
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angucyclinone
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rubiginone B2
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saccharosporone A
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saccharosporone B
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tetrangulol
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fujianmycin A
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ochromycinone