A mysterious case of gastroparesis: could the secret be found in a drink?

Inflamm Allergy Drug Targets. 2013 Jun;12(3):187-9. doi: 10.2174/1871528111312030005.

Abstract

Background: Gastroparesis is a disorder characterized by delayed gastric emptying of a meal in the absence of a mechanical gastric outlet obstruction. Idiopathic gastroparesis is at least as common as diabetic gastroparesis in most case series, and the true prevalence of gastroparesis is unknown.

Results: We report here an interesting case of idiopathic gastroparesis characterized by sudden onset in a female patient. The diagnosis was confirmed by ultrasonographic study of gastric emptying and electrogastrography, by gastric endoscopy/histology, and finally by allergy tests. The disorder was found to be due to a rare cause, namely an allergic predisposition. In fact, our patient, who demonstrated an allergy to gold salts, had drunk a glass of a liqueur containing gold flakes and developed an eosinophilic aggregation in the gastric mucosa observed at gastric endoscopy/histology. The symptoms disappeared after steroid administration.

Conclusion: Our experience suggests that gastric histology and close enquiry into any history of allergy may be useful diagnostic tools in cases of idiopathic gastroparesis.

Publication types

  • Case Reports

MeSH terms

  • Alcoholic Beverages / adverse effects
  • Allergens / adverse effects
  • Allergens / immunology
  • Allergens / ultrastructure
  • Endoscopy, Digestive System
  • Eosinophils / immunology*
  • Female
  • Gastric Mucosa / immunology*
  • Gastroenteritis / diagnosis*
  • Gastroenteritis / etiology
  • Gastroenteritis / immunology
  • Gold / adverse effects
  • Gold / chemistry
  • Gold / immunology
  • Humans
  • Hypersensitivity / complications
  • Hypersensitivity / diagnosis*
  • Hypersensitivity / immunology
  • Microscopy, Electron
  • Middle Aged
  • Phagocytes / metabolism*
  • Phagocytes / ultrastructure

Substances

  • Allergens
  • Gold