Purpose: To evaluate the accuracy and reproducibility of retinal thickness measurements in healthy and epiretinal membranes (ERM) eyes by Cirrus and Spectralis Fourier-domain optical coherence tomography devices.
Methods: Eighty-seven ERM and 122 healthy subjects underwent 3 macular scans using both optical coherence tomography instruments. Mean thickness measurements in the nine Early Treatment Diabetic Retinopathy Study areas were compared, evaluating the repeatability and the relationship between devices.
Results: Macular thickness increase was detected in ERM eyes for all optical coherence tomography parameters (P < 0.001). Mean foveal thickness was 423.5 ± 81.4 and 438.0 ± 54.2 μm for ERM eyes and 267.1 ± 20.2 and 277.5 ± 18.9 μm for healthy eyes using Cirrus and Spectralis, respectively. Macular average thickness in ERM eyes as determined by both optical coherence tomography was correlated (r = 0.812; P < 0.001) but significantly different (P = 0.044). In ERM eyes, measurements showed a mean of the coefficients of variation of 2.95%, 2.2%, and 1.01% using Cirrus, Spectralis, and Spectralis progression feature, respectively. Intraclass correlation coefficients were higher than 0.919 in all cases.
Conclusion: Reproducibility of both Cirrus and Spectralis optical coherence tomography was high in healthy and ERM eyes. However, considerable differences were found between macular thickness measurements obtained by both devices despite the high correlation between them.