Opaciniols A-C, new terpenoids from Garcinia opaca

Reika Mori; Alfarius Eko Nugroho; Yusuke Hirasawa; Chin Piow Wong; Toshio Kaneda; Osamu Shirota; A Hamid A Hadi; Hiroshi Morita

doi:10.1007/s11418-013-0764-1

Opaciniols A-C, new terpenoids from Garcinia opaca

J Nat Med. 2014 Jan;68(1):186-91. doi: 10.1007/s11418-013-0764-1. Epub 2013 Mar 28.

Authors

Reika Mori¹, Alfarius Eko Nugroho, Yusuke Hirasawa, Chin Piow Wong, Toshio Kaneda, Osamu Shirota, A Hamid A Hadi, Hiroshi Morita

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo, 142-8501, Japan.

PMID: 23536319
DOI: 10.1007/s11418-013-0764-1

Abstract

Three new terpenoids, opaciniols A-C (1-3), were isolated from the barks of Garcinia opaca, together with malabarica-17,21-dien-3β,14-diol (4) and 13βH-malabarica-14,17,21-trien-3β-ol (5). Their structures were determined on the basis of NMR spectroscopic data. 3 and 4 showed moderate cytotoxicity against HL-60 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Survival / drug effects
Garcinia / chemistry*
HL-60 Cells
Humans
Inhibitory Concentration 50
Leukemia, Promyelocytic, Acute / pathology
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Structure
Phytotherapy
Plant Bark
Plants, Medicinal
Terpenes / chemistry
Terpenes / isolation & purification*

Substances

Antineoplastic Agents, Phytogenic
Terpenes