Abstract
The synthesis and characterization of a highly photostable bromo-substituted BODIPY dye (I) fused-ring-expanded with thienopyrrole moieties is reported. The results of MTT assays and flow cytometric analyses in living HeLa cells demonstrate that I has a high singlet oxygen quantum yield (ΦΔ = 0.63) and exhibits photocytotoxicity upon irradiation in the NIR region making it potentially suitable for use in PDT.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Boron Compounds / chemistry
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Boron Compounds / therapeutic use*
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Cell Survival / drug effects
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Cell Survival / radiation effects
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HeLa Cells
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Humans
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Neoplasms / drug therapy*
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Photochemotherapy* / methods
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / therapeutic use*
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Pyrroles / chemistry
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Pyrroles / therapeutic use*
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Boron Compounds
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Photosensitizing Agents
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Pyrroles
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thienopyrrole