Abstract
β-Lactam antibiotics are one of the most important antibiotic classes but are plagued by problems of resistance, and the development of new β-lactam antibiotics through side-chain modification of existing β-lactam classes is not keeping pace with resistance development. In this JOCSynopsis, we summarize small molecule strategies to overcome resistance to β-lactam antibiotics. These approaches include the development of β-lactamase inhibitors and compounds that interfere with the ability of the bacteria to sense an antibiotic threat and activate their resistance mechanisms.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Drug Discovery
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Molecular Structure
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Small Molecule Libraries* / chemical synthesis
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Small Molecule Libraries* / chemistry
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Small Molecule Libraries* / pharmacology
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beta-Lactam Resistance / drug effects*
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beta-Lactamase Inhibitors
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beta-Lactams* / chemical synthesis
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beta-Lactams* / chemistry
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beta-Lactams* / pharmacology
Substances
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Anti-Bacterial Agents
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Small Molecule Libraries
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beta-Lactamase Inhibitors
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beta-Lactams