Abstract
Monoesters of ginsenoside metabolite M1 at the 3-OH, 4-OH and 6-OH positions of the glucose moiety at M1 were synthesized via the reaction of M1 with acyl chloride, or acid-N,N'-diisopropylcarbodiimide in the presence of DMAP. Their structures were fully characterized by spectral methods. The cytotoxicity of these compounds against then MGC80-3 human gastric cancer cell line was also assessed. High inhibitory effects were found at a concentration of 100 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Carbodiimides / analysis
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Carbodiimides / chemistry
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Cell Line, Tumor
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Ginsenosides / chemical synthesis*
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Ginsenosides / pharmacology*
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Humans
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Molecular Structure
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Pyridines / analysis
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Pyridines / chemistry
Substances
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4-(dimethylamine)pyridine
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Antineoplastic Agents
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Carbodiimides
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Ginsenosides
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Pyridines
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1,3-diisopropylcarbodiimide
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ginsenoside M1