Improved synthesis of 3-aryl isoxazoles containing fused aromatic rings

Tetrahedron. 2012 Dec 16;68(50):10360-10364. doi: 10.1016/j.tet.2012.09.084. Epub 2012 Sep 25.

Abstract

A critical comparison of methods to prepare sterically hindered 3-aryl isoxazoles containing fused aromatic rings using the nitrile oxide cycloaddition (NOC) reveal that modification of the method of Bode, Hachisu, Matsuura, and Suzuki (BHMS), utilizing either triethylamine as base or sodium enolates of the diketone, ketoester, and ketoamide dipolarophiles, respectively, was the method of choice for this transformation.