Abstract
Cu(OTf)2 catalyzed efficient synthesis of spiropyrano[3,2-b]pyran-4(8H)-ones is accomplished via one-pot three component reaction between isatin, kojic acid and active methylenes. This synthetic protocol is operationally simple and affords product with good to excellent yields at a short reaction time. The synthesized compounds were evaluated for their tumor cell growth inhibitory activity against the human lung cancer cell line (A549) and found that 13 compounds exhibited moderate to good anticancer potency. Molecular docking studies were performed for all the synthesized compounds and the results showed that compound 4e showed greater affinity for anaplastic lymphoma kinase (ALK) receptor.
Copyright © 2013 Elsevier Ltd. All rights reserved.
MeSH terms
-
Anaplastic Lymphoma Kinase
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / toxicity
-
Binding Sites
-
Catalysis
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Crystallography, X-Ray
-
Humans
-
Isatin / chemistry
-
Lung Neoplasms / metabolism
-
Lung Neoplasms / pathology
-
Mesylates / chemistry*
-
Molecular Conformation
-
Molecular Docking Simulation
-
Protein Structure, Tertiary
-
Pyrans / chemical synthesis
-
Pyrans / chemistry*
-
Pyrans / toxicity
-
Pyrones / chemistry
-
Receptor Protein-Tyrosine Kinases / chemistry
-
Receptor Protein-Tyrosine Kinases / metabolism
-
Spiro Compounds / chemistry*
Substances
-
Antineoplastic Agents
-
Mesylates
-
Pyrans
-
Pyrones
-
Spiro Compounds
-
kojic acid
-
Isatin
-
ALK protein, human
-
Anaplastic Lymphoma Kinase
-
Receptor Protein-Tyrosine Kinases
-
trifluoromethanesulfonic acid