Abstract
A series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4-bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging from 5.7 ± 0.8-12 ± 1.2 μM, and its cytotoxicity to Vero cells (TC50 = 620 ± 0.0 μM) was far lower than that of pirodavir (TC50 = 31 ± 2.2 μM). Based on these results, compound 1e is a promising lead compound for the development of anti-EV 71 drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Antiviral Agents / toxicity
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Benzamides / chemical synthesis*
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Benzamides / pharmacology
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Benzamides / toxicity
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Chlorocebus aethiops
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Drug Evaluation, Preclinical
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Enterovirus / drug effects
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Inhibitory Concentration 50
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Piperidines / pharmacology
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Piperidines / toxicity
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Pyridazines / pharmacology
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Pyridazines / toxicity
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Structure-Activity Relationship
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Vero Cells
Substances
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Antiviral Agents
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Benzamides
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Piperidines
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Pyridazines
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pirodavir