Abstract
A novel series of compounds were synthesized by cyclic condensation reaction of substituted isothiocyanate (2a-c) with 2-thiophenecarboxylic acid hydrazide (1) in the presence of ethyl alcohol, to obtain intermediate thiosemicarbazides (3a-c), which were further treated with sodium hydroxide in the presence of ethanol to obtain triazole derivatives (4a-c). The latter were refluxed with substituted secondary amines and formaldehyde for 6-10 h to afford Mannich bases (5a-k). The synthesized compounds were characterized on the basis of their spectral (IR, (13)C and (1)H NMR) data and evaluated for biological activities. Some of the compounds were found to exhibit significant antimicrobial and antioxidant activity.
Copyright © 2013 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Antioxidants / chemical synthesis
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Aspergillus flavus / drug effects
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Aspergillus fumigatus / drug effects
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Biphenyl Compounds / metabolism
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Dose-Response Relationship, Drug
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Escherichia coli / drug effects
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology
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Microbial Sensitivity Tests
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Models, Chemical
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Molecular Structure
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Oxidation-Reduction / drug effects
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Penicillium / drug effects
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Picrates / metabolism
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Staphylococcus aureus / drug effects
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Thiones / chemical synthesis*
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Thiones / chemistry
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Thiones / pharmacology
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Triazoles / chemical synthesis*
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Triazoles / chemistry
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Triazoles / pharmacology
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Trichophyton / drug effects
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Antioxidants
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Biphenyl Compounds
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Free Radical Scavengers
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Picrates
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Thiones
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Triazoles
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1,2,4-triazole
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1,1-diphenyl-2-picrylhydrazyl