PAMAM dendrimer roles in gene delivery methods and stem cell research

Cell Biol Int. 2013 May;37(5):415-9. doi: 10.1002/cbin.10051. Epub 2013 Mar 18.

Abstract

Nanotechnology has provided new technological opportunities, which could help in challenges confronting stem cell research. Polyamidoamine (PAMAM) dendrimers, a new class of macromolecular polymers with high molecular uniformity, narrow molecular distribution specific size and shape and highly functionalised terminal surface have been extensively explored for biomedical application. PAMAM dendrimers are also nanospherical, hyperbranched and monodispersive molecules exhibiting exclusive properties which make them potential carriers for drug and gene delivery.

Publication types

  • Review

MeSH terms

  • Cellular Reprogramming
  • Dendrimers / chemistry*
  • Gene Transfer Techniques*
  • Induced Pluripotent Stem Cells / cytology
  • Induced Pluripotent Stem Cells / metabolism
  • Nanotechnology
  • Transcription Factors / metabolism

Substances

  • Dendrimers
  • PAMAM Starburst
  • Transcription Factors