RIG-I goes beyond naked recognition

J Bradford Bowzard; Priya Ranjan; Suryaprakash Sambhara

doi:10.1016/j.chom.2013.02.012

RIG-I goes beyond naked recognition

Cell Host Microbe. 2013 Mar 13;13(3):247-9. doi: 10.1016/j.chom.2013.02.012.

Authors

J Bradford Bowzard¹, Priya Ranjan, Suryaprakash Sambhara

Affiliation

¹ Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.

PMID: 23498950
DOI: 10.1016/j.chom.2013.02.012

Abstract

It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors.

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