Inhalable particulate has become the premier pollutant of Beijing, which has enormous influence on the environmental quality of the city and health of the residents. Inhalable particle pollutants (particulate matter of 0.3, 0.5, 3.0 and 5.0 microm) during the heating period and the non-heating period in 2008 and 2009 were collected, and spatial analysis was used to study the spatial distribution of each pollutant. Meanwhile, the hospital data about respiratory disease during the same time was gathered and counted. Then the relativity between inhalable particulate pollutants and respiratory disease was studied by grey correlation analysis on the base of regression analysis. The results showed that spatial distribution of fine particle was diverse but the pattern of coarse particle was similar. There was certain association between respiratory disease and inhalable particle pollutants. Heating period was the highest incidence period of respiratory disease. The prevalence of respiratory disease was higher in heating period than non-heating period. The concentration of fine particle was higher than that of coarse particle both in heating and non-heating periods, and fine particle had more effects on the respiratory system disease than coarse particle.