Synthesis and antitumor activity of novel chalcone derivatives

Chuanfei Jin; Yong-Ju Liang; Hongwu He; Liwu Fu

doi:10.1016/j.biopha.2010.12.010

Synthesis and antitumor activity of novel chalcone derivatives

Biomed Pharmacother. 2013 Apr;67(3):215-7. doi: 10.1016/j.biopha.2010.12.010. Epub 2010 Dec 30.

Authors

Chuanfei Jin¹, Yong-Ju Liang, Hongwu He, Liwu Fu

Affiliation

¹ Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152, Luoyu Road, Wuhan 430079, PR China.

PMID: 23478573
DOI: 10.1016/j.biopha.2010.12.010

Abstract

A novel series of chalcone derivatives containing pyrimidinyl group were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines. Most of the prepared compounds showed potential cytotoxicity against several human cancer cell lines. The compound 5g displayed more potent cytotoxic activities against human cancer cell lines in comparison with Curcumin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / therapeutic use
Cell Line, Tumor
Chalcone / chemical synthesis*
Chalcone / therapeutic use
Curcumin / chemical synthesis
Curcumin / therapeutic use
Drug Screening Assays, Antitumor / methods
Humans
K562 Cells
MCF-7 Cells
Neoplasms / drug therapy
Structure-Activity Relationship

Substances

Antineoplastic Agents
Chalcone
Curcumin