Gigantecin: a novel antimitotic and cytotoxic acetogenin, with nonadjacent tetrahydrofuran rings, from Goniothalamus giganteus (Annonaceae)

Experientia. 1990 May 15;46(5):539-41. doi: 10.1007/BF01954260.

Abstract

Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid gamma-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark of Goniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents*
  • Chemical Phenomena
  • Chemistry
  • Drug Screening Assays, Antitumor
  • Furans / analysis
  • Furans / isolation & purification
  • Furans / pharmacology*
  • Humans
  • Lactones / analysis
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Plant Extracts / analysis
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology

Substances

  • Antineoplastic Agents
  • Furans
  • Lactones
  • Plant Extracts
  • gigantecin
  • tetrahydrofuran